Application of an omonasteine ligation strategy for the total chemical synthesis of the BRD7 bromodomain.
نویسندگان
چکیده
The use of omonasteine (Omo) in sequential peptide ligation strategies extends the scope of homocysteine (Hcy) ligation to longer, methionine-rich proteins. Hcy-to-Omo conversion can be performed on-resin, while the Omo-to-Hcy deprotection can be performed in situ after peptide ligation. This strategy was successfully applied in the synthesis of the BRD7 bromodomain.
منابع مشابه
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ورودعنوان ژورنال:
- Chemical communications
دوره 48 75 شماره
صفحات -
تاریخ انتشار 2012